Chris and his Oxford-based lab team are investigating molecular pathogenesis and molecular immunology of large variant multi-gene families in Plasmodium falciparum. As a longstanding collaborator and honorary faculty member of the Wellcome Trust Sanger Institute, he played a leading role in producing the first Plasmodium genome sequence. Chris also helped to establish the Wellcome Trust Unit in Kenya, now the KEMRI-Wellcome Trust Research Programme, with which he continues to work closely.