Paul's major focus was the development of web-based software for visualisation and analysis of large-scale genome variation data for pathogen and vector populations. He was the chief architect of the MalariaGEN Plasmodium falciparum web application and the Panoptes software framework. The components of this framework are designed to be repurposed for other similar large-scale projects, and have been adapted to MalariaGEN’s Plasmodium and Anopheles projects. Paul has a background in theoretical physics and a long history developing bioinformatics applications. In 1994, he founded the company Applied Maths from which he developed the BioNumerics software suite, which has become a global standard for the analysis of bacterial molecular typing data.