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Dr Carolyne Ndila




KEMRI-Wellcome Trust Research Programme, Kenya

Carolyne's research interests are human population genetics and genetic epidemiology with particular emphasis on malaria. It's estimated that 25% of the total variation in both uncomplicated and hospital-admitted malaria in a Kenya cohort can be explained by host genes, yet only a small fraction of the malaria-protective polymorphisms have so far been discovered. Carolyne's ongoing work includes investigating the genetic determinants of severe malaria including known variants such as HbS, G6PD deficiency and alpha-thalassaemia, as well as novel candidates arising from genome-wide association analysis, and exploring the wider impacts of these variants when co-inherited with one another. This work is being jointly supervised by Prof Tom Williams at KEMRI-Wellcome Trust Research Programme and Dr Kirk Rockett at the University of Oxford. Before commencing her PhD project, Carolyne was supported by the CGGH to undertake an MSc in Applied Statistics at the University of Oxford, which gave her the quantitative background necessary to analyse large and complex genetic datasets. Carolyne was also a MalariaGEN Data Fellow and has contributed to MalariaGEN Consortial Projects 1 and 2.

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