Alfredo has been working on malaria since 1996, when he started his doctorate studying the molecular epidemiology of P. falciparum in southern Mozambique. Between 2002-04, he undertook his postdoctoral research at the International Center for Genetic Engineering and Biotechnology (ICGEB; New Delhi, India), where he developed molecular methods to map the receptor-binding residues of P. falciparum molecules, an important step towards understanding the basis of these interactions and the natural acquisition of immunity.
In 2004, Alfredo returned to Spain and started his research at the Barcelona Center for International Health Research (CRESIB) and the Manhiça Health Research Center (CISM, Mozambique). He’s focused on the physiopathology of severe malaria in pregnant women and children, with a special interest in the identification of clinically relevant cytoadhesion phenotypes in P. falciparum and P. vivax, in the host and parasite molecules involved as well as in the targets of protective immune mechanisms. Alfredo is also evaluating the effect of drug-based interventions such as intermittent preventive treatment on the development of parasite resistance. He is currently working on the development of tools for malaria elimination, such as a serological assay to assess transmission among sentinel groups such as pregnant women, and the identification of hidden malaria infections in the bone marrow and other organs of the host. Alfredo joined the Plasmodium Diversity Network Africa in October 2014