Djimdé leads a research group at the University of Science, Techniques and Technologies of Bamako that is working to understand how genome variation in the Plasmodium falciparum parasite, its human host, and the Anopeheles gambaie mosquito vector contribute to the mechanisms of malaria disease spread. This work includes a translational research programme aimed at using molecular and genetic approaches to tackle important problems in malaria control, particularly antimalarial drug resistance. Djimdé is involved in several CGGH collaborations. He played an important role in the early establishment of MalariaGEN, participating in several consortial projects investigating human immune responses to malaria. Djimdé is also active in the development of the MalariaGEN Plasmodium falciparum Community Project, and provides leadership to the Plasmodium Diversity Network Africa (PDNA).