MalariaGEN
The Malaria Genomic Epidemiology Network (MalariaGEN) is a global community of researchers working together to integrate epidemiology with genome science. Understanding the genetic diversity in the human host, the parasite and the mosquito vector requires the coordinated effort of researchers around the world, and has a fundamental role to play in malaria control and elimination. This type of multi-centre, global collaboration must be underpinned by ethical frameworks, supported by robust technical infrastructure and analytical tools to assist researchers. The MRC Centre for Genomics and Global Health (CGGH) is supporting MalariaGEN by developing web-based applications for sharing and analysing large genomic datasets, and by helping to build research capacity for genetic epidemiology research in malaria-endemic regions.
Case studies
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This global collaboration enables researchers to analyse P. falciparum genome variation in clinical samples that they have collected and provides a web atlas of parasite polymorphism by aggregating genome variation data from multiple studies. We're supporting these efforts by providing expertise for population genetic analysis, web application development and research capacity building.
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Learn how we helped build a web application for the MalariaGEN P. falciparum Community Project that visualises genomic and population genetic data. Importantly, the application connects this data to information about the scientific community that generated it—shedding light on the genetic diversity of this lethal malaria parasite, as well as the researchers who are fighting it.
Publications
- Miotto O, Amato R, Ashley EA et al. Nature Genetics, 2015; Jan 19: AOP
- Malaria Genomic Epidemiology Network et al. Nature Genetics, 2014; Nov;46(11): 1197-1204
- Miotto O, Almagro-Garcia J, Manske M et al. Nature Genetics, 2013; Jun;45(6): 648-55.